Allen HL, Flanagan SE, Shaw-Smith C, De Franco E, Akerman I, Caswell R, the International Pancreatic Agenesis Consortium, Ferrer J, Hattersley AT, Ellard S.
GATA6 haploinsufficiency causes pancreatic agenesis in humans
Nat Genet. 2011 Dec 11;44(1):20-22. (pdf)

Molero X, Vaquero EC, Flández M, González AM, Ortiz MA, Cibrián-Uhalte E, Servitja JM, Merlos A, Juanpere N, Massumi M, Skoudy A, Macdonald R, Ferrer J, Real FX.
Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis
Gut. 2011 Sep 23. (pdf)

Nammo T, Rodríguez-Seguí SA, Ferrer J.
Mapping open chromatin with formaldehyde-assisted isolation of regulatory elements
Methods Mol Biol. 2011;791:287-96. (pdf)

Kirkpatrick CL, Wiederkehr A, Baquie M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB
Hepatic nuclear factor 1α (Hnf1α) dysfunction downregulates X-box binding protein 1 (Xbp1) and sensitises β-cells to endoplasmic reticulum stress
J Biol Chem. 2011 Sep 16;286(37):32300-12. Epub 2011 Jul 22. (pdf)

Ildem Akerman, Joris van Arensbergen, Jorge Ferrer
Removing the Brakes on Cell Identity
Dev Cell. 2011 Apr 19;20(4):411-2. (pdf)

Hunter CS, Maestro MA, Raum JC, Guo M, Thompson FH 3rd, Ferrer J, Stein R.
Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression
Mol Endocrinol. 2011 Feb;25(2):339-47. Epub 2010 Dec 30

Jorge Ferrer
Glucose as a Mitogenic Hormone
Cell Metab. 2011 Apr 6;13(4):357-8. (pdf)

Sylvia F. Boj, Dimitri Petrov, Jorge Ferrer
Epistasis of Transcriptomes Reveals Synergism Between Transcriptional Activators Hnf1α and Hnf4α
PLoS Genetics, 2010 May 27;6(5):e1000970.

Joris van Arensbergen, Javier García-Hurtado, Ignasi Moran, Miguel Angel Maestro, Xiaobo Xu, Mark Van de Casteele, Anouchka L. Skoudy, Matteo Palassini, Harry Heimberg, Jorge Ferrer
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing β-cells to adopt a neural gene activity program
Genome Res. 2010 Jun;20(6):722-32. Epub 2010 Apr 15. (pdf) (supl.)

Gaulton KJ *, Nammo T *, Pasquali L *, Simon J , Giresi PG , Fogarty MP , Panhuis TM , Mieczkowski P , Secchi A , Bosco D , Berney T , Montanya E , Mohlke KL , Lieb JD , Ferrer J
A map of open chromatin in human pancreatic islets
Nat Genet. 2010 Mar;42(3):255-9. Epub 2010 Jan 31. (pdf) *equal contribution

Garin I*, Edghill E*, Akerman I*, Rubio-Cabezas O*, Rica I, Locke J, Maestro MA, Alshaikh A, Bundak R, Castillo G, Deeb A, Deiss D, Fernandez JM, Godbole K, Hussain K, O'Connell M, Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial R, Ugarte E, Vasanthi T, Neonatal Diabetes International group, Johnstone K, Flanagan SE, Martínez RE, Castaño C, Patch AM Fernández-Rebollo E, Raile K, Morgan N, Harries L, Castaño L, Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT
Recessive Mutations in the INS gene result in Neonatal Diabetes through reduced insulin biosynthesis
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3105-10. (pdf) *equal contribution

Solar M*, Cardalda C*, Houbracken I*, Martín M, Maestro M, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J.
Pancreatic exocrine duct cells give rise to insulin-producing ß-cells during embryogenesis but not after birth.
Dev Cell, 2009 Dec; 17 ( 6): 849-860. (pdf) *equal contribution

Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB.
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppresion.
Cell Metab. 2009 Aug; 10(2):110-8 PMID: 19696489

Servitja GM, Pignatelli M, Maestro MA, Cardalda C, Boj SF, Lozano J, Blanco E, Lafuente A, McCarthy MI, Sumoy L, Guigó R, Ferrer J.
Hnf1α (MODY3) controls tissue-specific transcriptiona programs and exerts opposed effects on cell growth in pancreatic islets and liver.
Mol Cell Biol. 2009 Jun; 29(11):2945-59. Epub 2009 Mar 16. PMID: 19289501

Luco RF*, Maestro MA*, Sadoni N, Zink D, Ferrer J.
Targeted deficiency of the transcriptional activator Hnf1α alters subnuclear positioning of its genomic targets.
PLoS Genet. 2008 May 23; 4(5):e1000079.*equal contribution
PMID: 18497863

Maestro MA, Cardalda C, Boj SF, Luco RF, Servitja JM, Ferrer J.
Distinct roles of HNF1ß, HNF1α, and HNF4α in regulating pancreas development, ß-cell function and growth.
Endocr Dev. 2007; 12:33-45. Review.
PMID: 17923767

Pearson ER*, Boj SF*, Steele AM*, Barrett T, Stals K, Shield JP, Ellard S, Ferrer J, Hattersley AT.
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.
PLoS Med. 2007 Apr; 4(4):e118.*equal contribution
PMID: 17407387

Ferrer J, Martín M, Servitja JM.
Putting pancreatic cell plasticity to the test.
J Clin Invest. 2007 Apr;117(4):859-62.
PMID: 17404611

Luco RF, Maestro MA, del Pozo N, Philbrick WM, de la Ossa PP, Ferrer J.
A conditional model reveals that induction of hepatocyte nuclear factor-1α in Hnf1α-null mutant ß-cells can activate silenced genes postnatally, whereas overexpression is deleterious.
Diabetes. 2006 Aug;55(8):2202-11.
PMID: 16873682

Ek J, Hansen SP, Lajer M, Nicot C, Boesgaard TW, Pruhova S, Johansen A, Albrechtsen A, Yderstraede K, Lauenborg J, Parrizas M, Boj SF, Jørgensen T, Borch-Johnsen K, Damm P, Ferrer J, Lebl J, Pedersen O, Hansen T.
A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 α gene (HNF4A) associates with late-onset diabetes.
Diabetes. 2006 Jun;55(6):1869-73.
PMID: 16731855

Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H.
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
EMBO J. 2006 Mar 22;25(6):1344-52. Epub 2006 Mar 2.
PMID: 16511571

Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP.
The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.
Gastroenterology. 2006 Feb;130(2):532-41.
PMID: 16472605

Servitja JM, Ferrer J.
Transcriptional networks controlling pancreatic development and ß-cell function.
Diabetologia. 2004 Apr;47(4):597-613. Review.
PMID: 15298336

Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J.
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
Hum Mol Genet. 2003 Dec 15;12(24):3307-14. Epub 2003 Oct 21.
PMID: 14570708

Párrizas M, Boj SF, Luco RF, Maestro MA, Ferrer J.
Chromatin immunoprecipitation using isolated islets of Langerhans.
Methods Mol Med. 2003;83:61-71. No abstract available.
PMID: 12619716

Mitchell SM, Vaxillaire M, Thomas H, Parrizas M, Benmezroua Y, Costa A, Hansen T, Owen KR, Tuomi T, Pirie F, Ryffel GU, Ferrer J, Froguel P, Hattersley AT, Frayling TM.
Rare variants identified in the HNF4α ß-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.
Diabetologia. 2002 Sep;45(9):1344-8. Epub 2002 Jul 19.
PMID: 12242469

Hansen SK*, Párrizas M*, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T.
Genetic evidence that HNF1α-dependent transcriptional control of HNF-4α is essential for human pancreatic ß cell function.
J Clin Invest. 2002 Sep;110(6):827-33. *equal contribution
PMID: 12235114

Ferrer J.
A genetic switch in pancreatic ß-cells: implications for differentiation and
haploinsufficiency.
Diabetes. 2002 Aug;51(8):2355-62. Review.
PMID: 12145145

Boj SF, Parrizas M, Maestro MA, Ferrer J.
A transcription factor regulatory circuit in differentiated pancreatic cells.
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14481-6. Epub 2001 Nov 20.
PMID: 11717395

Hansen T, Ambye L, Grarup N, Hansen L, Echwald SM, Ferrer J, Pedersen O.
Genetic variability of the SUR1 promoter in relation to ß-cell function and Type II diabetes mellitus.
Diabetologia. 2001 Oct;44(10):1330-4.
PMID: 11692183

Párrizas M, Maestro MA, Boj SF, Paniagua A, Casamitjana R, Gomis R, Rivera F,
Ferrer J.
Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets.
Mol Cell Biol. 2001 May;21(9):3234-43.
PMID: 11287626

Stoffers DA, Ferrer J, Clarke WL, Habener JF.
Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.
Nat Genet. 1997 Oct;17(2):138-9. (pdf)